Improving the Power of GWAS and Avoiding Confounding from Population Stratification with PC-Select
نویسندگان
چکیده
Using a reduced subset of SNPs in a linear mixed model can improve power for genome-wide association studies, yet this can result in insufficient correction for population stratification. We propose a hybrid approach using principal components that does not inflate statistics in the presence of population stratification and improves power over standard linear mixed models.
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